David Killilea, PhD

Director Martin Luther King (MLK) Core
+1 510 450-7993
Publications: 

A histochemical approach to activity-based copper sensing reveals cuproplasia-dependent vulnerabilities in cancer.

Proceedings of the National Academy of Sciences of the United States of America

Messina MS, Torrente L, Pezacki AT, Humpel HI, Li EL, Miller SG, Verdejo-Torres O, Padilla-Benavides T, Brady DC, Killilea DW, Killilea AN, Ralle M, Ward NP, Ohata J, DeNicola GM, Chang CJ

Change in Metabolomic Profile Associated with an Average Increase in Plain Water Intake of >+ 1 L/Day, Sustained Over 4 Weeks, in Healthy Young Men with Initial Total Water Intake Below 2 L/Day.

Paracelsus proceedings of experimental medicine

Stookey JD, Paulweber B, Felder TK, Lang F, Häussinger D, Killilea DW, Kuypers FA, Ritter M

Nutritional Anemia. Nutrition and Health

The Role of Zinc in the Etiology of Anemia

Killilea DW, Siekmann JH

Blood draw site and analytic device influence hemoglobin measurements.

PloS one

Killilea DW, Kuypers FA, Larkin SK, Schultz K

Kidney Stones in Transfusion-Dependent Thalassemia: Prevalence and Risk Factors

Open Journal of Urology

Sayani FA, Lal A, Tasian GE, Al Mukaddam M, Killilea DW, Wasserstein A, and Fung EB

Success of Distance Learning During 2020 COVID-19 Restrictions: A Report from Five STEM Training Programs for Underrepresented High School and Undergraduate Learners.

Journal of STEM outreach

Fung EB, Frey MR, Valmont ME, Caffey-Fleming DE, Fraser M, Williams J, Killilea DW, Bogenmann E, Livshits S, Boone DN

Zinc deficiency and its association with treatment-related toxicity in children with cancer.

Pediatric blood & cancer

Chung JH, Phalke N, Hastings C, Killilea DW, Feusner JH, Fung EB

Zinc supplementation improves markers of glucose homeostasis in thalassaemia.

British journal of haematology

Fung EB, Ahmad T, Killilea DW, Hussain R, Lal A

Plasma and Nail Zinc Concentrations, But Not Hair Zinc, Respond Positively to Two Different Forms of Preventive Zinc Supplementation in Young Laotian Children: a Randomized Controlled Trial.

Biological trace element research

Wessells KR, Brown KH, Arnold CD, Barffour MA, Hinnouho GM, Killilea DW, Kounnavong S, Hess SY

Wheat germ agglutinin is a biomarker of whole grain content in wheat flour and pasta.

Journal of food science

Killilea DW, McQueen R, Abegania JR

Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.

Cell stem cell

Nobuta H, Yang N, Ng YH, Marro SG, Sabeur K, Chavali M, Stockley JH, Killilea DW, Walter PB, Zhao C, Huie P, Goldman SA, Kriegstein AR, Franklin RJM, Rowitch DH, Wernig M

A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.

PLoS genetics

Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P

Monitoring of the National Oil and Wheat Flour Fortification Program in Cameroon Using a Program Impact Pathway Approach.

Current developments in nutrition

Mark HE, Assiene JG, Luo H, Nankap M, Ndjebayi A, Ngnie-Teta I, Tarini A, Pattar A, Killilea DW, Brown KH, Engle-Stone R

Early maturing spring wheat in Nordic wildtype NAM-B1 germplasm for short-duration alternative wheat producing regions

Plant Genetic Resources

Econopouly BF, Van Veldhuizen BM, Lyon SR, Killilea DW, Zhang M, and Jones SS

Potassium restriction boosts vacuolar acidity and extends lifespan in yeast.

Experimental gerontology

Sasikumar AN, Killilea DW, Kennedy BK, Brem RB

Iron, Zinc, Folate, and Vitamin B-12 Status Increased among Women and Children in Yaoundé and Douala, Cameroon, 1 Year after Introducing Fortified Wheat Flour.

The Journal of nutrition

Engle-Stone R, Nankap M, Ndjebayi AO, Allen LH, Shahab-Ferdows S, Hampel D, Killilea DW, Gimou MM, Houghton LA, Friedman A, Tarini A, Stamm RA, Brown KH

Identification of a Hemolysis Threshold That Increases Plasma and Serum Zinc Concentration.

The Journal of nutrition

Killilea DW, Rohner F, Ghosh S, Otoo GE, Smith L, Siekmann JH, King JC

α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.

Nature medicine

Zee T, Bose N, Zee J, Beck JN, Yang S, Parihar J, Yang M, Damodar S, Hall D, O'Leary MN, Ramanathan A, Gerona RR, Killilea DW, Chi T, Tischfield J, Sahota A, Kahn A, Stoller ML, Kapahi P

A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations.

The American journal of clinical nutrition

Zyba SJ, Shenvi SV, Killilea DW, Holland TC, Kim E, Moy A, Sutherland B, Gildengorin V, Shigenaga MK, King JC

A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans.

Scientific reports

Khanna A, Kumar J, Vargas MA, Barrett L, Katewa S, Li P, McCloskey T, Sharma A, Naudé N, Nelson C, Brem R, Killilea DW, Mooney SD, Gill M, Kapahi P

Dietary Zinc and Incident Calcium Kidney Stones in Adolescence.

The Journal of urology

Tasian GE, Ross ME, Song L, Grundmeier RW, Massey J, Denburg MR, Copelovitch L, Warner S, Chi T, Killilea DW, Stoller ML, Furth SL

Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.

PloS one

Kumar J, Barhydt T, Awasthi A, Lithgow GJ, Killilea DW, Kapahi P

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Science translational medicine

Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR

Acute changes in cellular zinc alters zinc uptake rates prior to zinc transporter gene expression in Jurkat cells.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

Holland TC, Killilea DW, Shenvi SV, King JC

The elementome of calcium-based urinary stones and its role in urolithiasis.

Nature reviews. Urology

Ramaswamy K, Killilea DW, Kapahi P, Kahn AJ, Chi T, Stoller ML

Fertility in transfusion-dependent thalassemia men: effects of iron burden on the reproductive axis.

American journal of hematology

Singer ST, Killilea D, Suh JH, Wang ZJ, Yuan Q, Ivani K, Evans P, Vichinsky E, Fischer R, Smith JF

Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

Lee MJ, Alvarez JA, Smith EM, Killilea DW, Chmiel JF, Joseph PM, Grossmann RE, Gaggar A, Ziegler TR, Tangpricha V, Vitamin D for Enhancing the Immune System in Cystic Fibrosis Investigators

Elemental Content of Calcium Oxalate Stones from a Canine Model of Urinary Stone Disease.

PloS one

Killilea DW, Westropp JL, Shiraki R, Mellema M, Larsen J, Kahn AJ, Kapahi P, Chi T, Stoller ML

A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease.

PloS one

Chi T, Kim MS, Lang S, Bose N, Kahn A, Flechner L, Blaschko SD, Zee T, Muteliefu G, Bond N, Kolipinski M, Fakra SC, Mandel N, Miller J, Ramanathan A, Killilea DW, Brückner K, Kapahi P, Stoller ML

Iron promotes protein insolubility and aging in C. elegans.

Aging

Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, Lithgow GJ

Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.

Metallomics : integrated biometal science

Angeli S, Barhydt T, Jacobs R, Killilea DW, Lithgow GJ, Andersen JK

Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels.

Respiratory research

Hassan F, Xu X, Nuovo G, Killilea DW, Tyrrell J, Da Tan C, Tarran R, Diaz P, Jee J, Knoell D, Boyaka PN, Cormet-Boyaka E

Altered transition metal homeostasis in Niemann-Pick disease, type C1.

Metallomics : integrated biometal science

Hung YH, Faux NG, Killilea DW, Yanjanin N, Firnkes S, Volitakis I, Ganio G, Walterfang M, Hastings C, Porter FD, Ory DS, Bush AI

Zinc deficiency augments leptin production and exacerbates macrophage infiltration into adipose tissue in mice fed a high-fat diet.

The Journal of nutrition

Liu MJ, Bao S, Bolin ER, Burris DL, Xu X, Sun Q, Killilea DW, Shen Q, Ziouzenkova O, Belury MA, Failla ML, Knoell DL

ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.

Cell reports

Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL

Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans.

Metallomics : integrated biometal science

Page KE, White KN, McCrohan CR, Killilea DW, Lithgow GJ

Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts.

Proceedings of the National Academy of Sciences of the United States of America

Killilea DW, Ames BN

Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts.

Redox report : communications in free radical research

Lal A, Atamna W, Killilea DW, Suh JH, Ames BN

Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.

The Journal of biological chemistry

McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ

Zinc deficiency reduces paclitaxel efficacy in LNCaP prostate cancer cells.

Cancer letters

Killilea AN, Downing KH, Killilea DW

N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Voloboueva LA, Killilea DW, Atamna H, Ames BN

Steady-state asymmetric nanospray dual ion source for accurate mass determination within a chromatographic separation.

Analytical chemistry

Young NL, Sisto MC, Young MN, Grant PG, Killilea DW, LaMotte L, Wu KJ, Lebrilla CB

Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease.

British journal of haematology

Walter PB, Fung EB, Killilea DW, Jiang Q, Hudes M, Madden J, Porter J, Evans P, Vichinsky E, Harmatz P

Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging.

Molecular aspects of medicine

Ames BN, Atamna H, Killilea DW

Iron accumulation during cellular senescence.

Annals of the New York Academy of Sciences

Killilea DW, Wong SL, Cahaya HS, Atamna H, Ames BN

Iron accumulation during cellular senescence in human fibroblasts in vitro.

Antioxidants & redox signaling

Killilea DW, Atamna H, Liao C, Ames BN

Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging.

Proceedings of the National Academy of Sciences of the United States of America

Atamna H, Killilea DW, Killilea AN, Ames BN

Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Grishko V, Solomon M, Breit JF, Killilea DW, Ledoux SP, Wilson GL, Gillespie MN

Free radical production in hypoxic pulmonary artery smooth muscle cells.

American journal of physiology. Lung cellular and molecular physiology

Killilea DW, Hester R, Balczon R, Babal P, Gillespie MN